Prognostic evaluation of candidate selection Hangzhou criteria of hepatocellular carcinoma for liver transplantation after hepatectomy

Objective To evaluate the prognostic significance of the candidate selection Hangzhou criteria for liver transplantation of HCC patients undergoing hepatectomy. Methods 199 HCC patients undergoing hepatectomy between 2009 and 2011 were enrolled retrospectively. Predictors of survival were identified using the Kaplan-Meier method. The disease state was staged by the Hangzhou criteria (HC) and Milan staging systems. Calculating the area under the receiver operating characteristic (ROC) curve (AUC) evaluates the discriminatory ability for the prediction of survival of both staging system. Results Portal vein thrombosis, poor differentiation, and tumor size (>8 cm) were independent risk factors for survival after hepatectomy. Milan criteria and Hangzhou criteria functioned well in predicting tumor-recurrence. For 1-year AUROC, the AUROC for Milan criteria and Hangzhou criteria are 0.602 and 0.741, respectively. For 3-year AUROC, the AUROC for Milan criteria and Hangzhou criteria are 0.643 and 0.733, respectively. Conclusions The HC were shown to be a promising survival predictor in a Chinese cohort of HCC patients after hepatectomy. Key words: Carcinoma, hepatocellular; Hepatectomy; Reference standards