The importance in the experimental diagnosis value of exosome

Exosome is nanoscale vesicles with bilayer membrane structure, is secreted by multiple living cells in vivo, capable of carrying biological materials such as nucleic acids, proteins and lipids etc. Exosome can protect the information material (such as miRNA), which is easy to be inactivated or degraded in the circulatory system, so that they can be safely transferred to the specific target cells to participate in signal regulation, and play an important role in the information transmission between cells. Exosome is widely found in human blood, urine, pleural effusion and other body fluid samples, and can provide rich, stable, sensitive and specific biological information. As a kind of liquid biopsy specimen, exosome has a very high clinical application value in the future.(Chin J Lab Med, 2015, 38: 724-726) Key words: Exosomes; Proteins; MicroRNAs; Biological markers