Dexamethasone and post-adenotonsillectomy pain in children

医学 地塞米松 可视模拟标度 麻醉 呕吐 安慰剂 恶心 术后恶心呕吐 随机对照试验 临床终点 不利影响 外科 内科学 替代医学 病理
作者
Young Mi Kang,Eu Jeong Ku,Il Gu Jung,Min Hyuck Kang,Young-Seok Choi,Hahn Jin Jung
出处
期刊:Medicine [Wolters Kluwer]
卷期号:100 (2): e24122-e24122 被引量:11
标识
DOI:10.1097/md.0000000000024122
摘要

To assess the impact of intraoperative intravenous dexamethasone on the reduction of postoperative morbidity in children undergoing adenotonsillectomy.A double blind randomized controlled trial conducted among children undergoing adenotonsillectomy at a tertiary hospital in Korea from November 2018 to June 2019. Children were randomly assigned to receive dexamethasone (0.5 mg/kg, maximum dose 24 mg) or placebo intravenously after induction of anesthesia. The primary endpoint was the reduction of postoperative pain and postoperative nausea and vomiting (PONV); secondary endpoints were adverse effects like postoperative hemorrhage.The study included 105 children, and 67 were male. Their mean age was 6.2 ± 2.1 years. There was no significant difference between the groups in terms of demographic data or the operation time. The pain scores of the dexamethasone group were lower than those of the control group, but no significant difference was found (all P > .05). The average pain visual analog scale (VAS) during the study period (day 0-7) was 3.67 ± 1.59 and 4.40 ± 2.01 in the dexamethasone group and control group, respectively (P-value = .107). When we compared early pain VAS (day 0-2) and late pain VAS (day 5-7), the dexamethasone group showed significantly lower early mean VAS compared to the control group (4.55 ± 1.78 vs 5.40 ± 2.05, P-value = .046). The mean VAS for PONV was significantly lower in the dexamethasone group than in the control group (1.89 ± 2.22 vs 3.00 ± 2.37, P value = .044).In children undergoing adenotonsillectomy, dexamethasone decreased the early postoperative pain and PONV without increasing postoperative hemorrhage.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
李茵发布了新的文献求助10
1秒前
1秒前
2秒前
2秒前
wyl发布了新的文献求助10
3秒前
4秒前
4秒前
小小小值钱完成签到,获得积分20
6秒前
wangjue发布了新的文献求助10
7秒前
8秒前
8秒前
木可发布了新的文献求助10
9秒前
9秒前
wyl完成签到,获得积分10
11秒前
汉堡包应助三斤采纳,获得10
12秒前
wangqiuhong发布了新的文献求助10
14秒前
15秒前
失眠的夜梦关注了科研通微信公众号
15秒前
今后应助HIT_C采纳,获得10
16秒前
今后应助SuperZzz采纳,获得10
17秒前
ZONG发布了新的文献求助10
19秒前
Nugget发布了新的文献求助10
20秒前
李茵完成签到,获得积分10
22秒前
量子星尘发布了新的文献求助10
22秒前
汉堡包应助风趣的老太采纳,获得10
23秒前
DongWei95发布了新的文献求助30
25秒前
25秒前
25秒前
猪猪hero发布了新的文献求助10
25秒前
斯文念波发布了新的文献求助10
25秒前
27秒前
29秒前
29秒前
断数循环应助任峰采纳,获得10
30秒前
FIN应助wuyu采纳,获得30
34秒前
越野蟹完成签到 ,获得积分10
34秒前
36秒前
msjs完成签到,获得积分20
36秒前
37秒前
yu发布了新的文献求助10
38秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989406
求助须知:如何正确求助?哪些是违规求助? 3531522
关于积分的说明 11254187
捐赠科研通 3270174
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174