间充质干细胞
脐带
旁分泌信号
医学
再生医学
间质细胞
骨髓
疾病
再生(生物学)
免疫学
生物信息学
干细胞
癌症研究
病理
生物
内科学
细胞生物学
受体
作者
Martina Colicchia,Daniel A. Jones,Anne‐Marie Beirne,Mohsin Hussain,Deshan Weeraman,Krishnaraj S. Rathod,Jessry Veerapen,Mark W. Lowdell,Anthony Mathur
出处
期刊:Cytotherapy
[Elsevier BV]
日期:2019-09-17
卷期号:21 (10): 1007-1018
被引量:26
标识
DOI:10.1016/j.jcyt.2019.04.056
摘要
The human umbilical cord has recently emerged as an attractive potential source of mesenchymal stromal cells (MSCs) to be adopted for use in regenerative medicine. Umbilical cord MSCs (UC-MSCs) not only share the same features of all MSCs such as multi-lineage differentiation, paracrine functions and immunomodulatory properties, they also have additional advantages, such as no need for bone marrow aspiration and higher self-renewal capacities. They can be isolated from various compartments of the umbilical cord (UC) and can be used for autologous or allogeneic purposes. In the past decade, they have been adopted in cardiovascular disease and have shown promising results mainly due to their pro-angiogenic and anti-inflammatory properties. This review offers an overview of the biological properties of UC-MSCs describing available pre-clinical and clinical data with respect to their potential therapeutic use in cardiovascular regeneration, with current challenges and future directions discussed.
科研通智能强力驱动
Strongly Powered by AbleSci AI