Laryngeal Dysfunction in Severe Asthma: A Cross-Sectional Observational Study

医学 哮喘 声带功能障碍 发声 观察研究 喉疾病 内科学 外科 听力学
作者
Anne E. Vertigan,Sarah L. Kapela,Peter G. Gibson
出处
期刊:The Journal of Allergy and Clinical Immunology: In Practice [Elsevier BV]
卷期号:9 (2): 897-905 被引量:23
标识
DOI:10.1016/j.jaip.2020.09.034
摘要

Background Laryngeal disorders can contribute to disease burden in severe asthma yet the nature of laryngeal disorders in severe asthma is poorly understood. Objective The aim of this study was to examine laryngeal function in patients with severe asthma. Method A cross-sectional observational study involving 97 participants compared laryngeal function in patients with severe asthma (n = 53) with patients with laryngeal disorders of vocal cord dysfunction/inducible laryngeal obstruction (n = 16) and muscle tension dysphonia (n = 14), and with healthy controls (n = 13). A pre-post pilot study of speech pathology intervention for laryngeal symptoms was then provided to 11 participants with severe asthma and laryngeal dysfunction. Results Laryngeal dysfunction was common in severe asthma. The majority of participants with severe asthma (87%) had laryngeal dysfunction, which affected respiration, phonation, or both. Three distinct patterns of laryngeal dysfunction in severe asthma were identified: (1) phonatory laryngeal dysfunction, (2) respiratory laryngeal dysfunction, and (3) combined laryngeal dysfunction. Laryngeal hypersensitivity and impaired voice measures were common in severe asthma. Patient-reported outcome measures improved after therapy, and laryngeal dysfunction improved in 7 (64%) participants. Conclusion Laryngeal dysfunction affects respiration and phonation in severe asthma. It requires identification and treatment to minimize its impact on asthma symptoms. Laryngeal disorders can contribute to disease burden in severe asthma yet the nature of laryngeal disorders in severe asthma is poorly understood. The aim of this study was to examine laryngeal function in patients with severe asthma. A cross-sectional observational study involving 97 participants compared laryngeal function in patients with severe asthma (n = 53) with patients with laryngeal disorders of vocal cord dysfunction/inducible laryngeal obstruction (n = 16) and muscle tension dysphonia (n = 14), and with healthy controls (n = 13). A pre-post pilot study of speech pathology intervention for laryngeal symptoms was then provided to 11 participants with severe asthma and laryngeal dysfunction. Laryngeal dysfunction was common in severe asthma. The majority of participants with severe asthma (87%) had laryngeal dysfunction, which affected respiration, phonation, or both. Three distinct patterns of laryngeal dysfunction in severe asthma were identified: (1) phonatory laryngeal dysfunction, (2) respiratory laryngeal dysfunction, and (3) combined laryngeal dysfunction. Laryngeal hypersensitivity and impaired voice measures were common in severe asthma. Patient-reported outcome measures improved after therapy, and laryngeal dysfunction improved in 7 (64%) participants. Laryngeal dysfunction affects respiration and phonation in severe asthma. It requires identification and treatment to minimize its impact on asthma symptoms.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
阿牛哥发布了新的文献求助10
刚刚
香蕉觅云应助东晓采纳,获得10
1秒前
1秒前
姜磊完成签到,获得积分20
2秒前
2秒前
xxddw发布了新的文献求助10
3秒前
3秒前
谢海洋完成签到,获得积分10
4秒前
5秒前
loski发布了新的文献求助10
6秒前
7秒前
xueyu发布了新的文献求助10
8秒前
9秒前
lincy完成签到,获得积分10
10秒前
fqk完成签到,获得积分10
10秒前
11秒前
hanleiharry1发布了新的文献求助10
11秒前
11秒前
13秒前
乐乐应助WN采纳,获得10
15秒前
辛勤的刺猬完成签到 ,获得积分10
19秒前
神奇宝贝发布了新的文献求助10
19秒前
19秒前
丘比特应助sssyq采纳,获得10
20秒前
20秒前
芝麻福福完成签到,获得积分10
20秒前
FYm完成签到,获得积分10
21秒前
心灵美孤菱完成签到,获得积分10
21秒前
田様应助阳光怀亦采纳,获得50
22秒前
阿牛哥关注了科研通微信公众号
23秒前
zsl完成签到,获得积分10
25秒前
26秒前
东晓发布了新的文献求助10
26秒前
娴娴完成签到,获得积分10
27秒前
hanleiharry1发布了新的文献求助10
28秒前
乖猫要努力应助pppp采纳,获得10
28秒前
Akim应助坚强的严青采纳,获得10
28秒前
29秒前
29秒前
31秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989390
求助须知:如何正确求助?哪些是违规求助? 3531487
关于积分的说明 11254109
捐赠科研通 3270153
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809174