Hypertrophic obstructive cardiomyopathy remains one of the more common inherited cardiac disorders with often a major impact on quality of life. Even today, most frequently a sternotomy is performed to conduct the myectomy. Several minimally invasive procedures, under direct vision or through transmitral access, have been demonstrated to operate on these patients. However, we believe our video-assisted transaortic approach could provide a more precise and complete resection than other minimally invasive approaches because of a clearer visualization of the septum and outflow tract. This could further increase the benefits for these patients and potentially make more frail patients eligible for surgical intervention. Hypertrophic obstructive cardiomyopathy remains one of the more common inherited cardiac disorders with often a major impact on quality of life. Even today, most frequently a sternotomy is performed to conduct the myectomy. Several minimally invasive procedures, under direct vision or through transmitral access, have been demonstrated to operate on these patients. However, we believe our video-assisted transaortic approach could provide a more precise and complete resection than other minimally invasive approaches because of a clearer visualization of the septum and outflow tract. This could further increase the benefits for these patients and potentially make more frail patients eligible for surgical intervention.