Novel strategies to eradicate resistant cells in chronic myeloid leukemia

髓系白血病 癌症研究 医学 白血病 计算生物学 生物 免疫学
作者
Anna M. Schoepf,Ronald Gust
出处
期刊:Future Medicinal Chemistry [Newlands Press Ltd]
卷期号:12 (23): 2089-2092
标识
DOI:10.4155/fmc-2020-0278
摘要

Future Medicinal ChemistryVol. 12, No. 23 EditorialNovel strategies to eradicate resistant cells in chronic myeloid leukemiaAnna M Schoepf & Ronald GustAnna M Schoepf https://orcid.org/0000-0002-7536-1906Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI – Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB – Centrum for Chemistry & Biomedicine, Innrain 80–82, 6020 Innsbruck, Austria & Ronald Gust *Author for correspondence: E-mail Address: ronald.gust@uibk.ac.athttps://orcid.org/0000-0002-0427-4012Department of Pharmaceutical Chemistry, Institute of Pharmacy, CMBI – Center for Molecular Biosciences Innsbruck, University of Innsbruck, CCB – Centrum for Chemistry & Biomedicine, Innrain 80–82, 6020 Innsbruck, AustriaPublished Online:24 Nov 2020https://doi.org/10.4155/fmc-2020-0278AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: cancer stem cells (CSCs)cell death modulatorschronic myeloid leukemia (CML)sensitizerstherapy resistancetyrosine kinase inhibitor (TKI)References1. 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Leukemia 21, 926–935 (2007).Crossref, Medline, CAS, Google Scholar10. Winer ES, DeAngelo DJ. A review of omacetaxine: a chronic myeloid leukemia treatment resurrected. Oncol. Ther. 6(1), 9–20 (2018).Crossref, Medline, Google Scholar11. Mitchell R, Hopcroft LEM, Baquero P et al. Targeting BCR-ABL-independent TKI resistance in chronic myeloid leukemia by mTOR and autophagy inhibition. J. Natl. Cancer Inst. 110(5), 467–478 (2017).Crossref, Google Scholar12. Wagle M, Eiring AM, Wongchenko M et al. A role for FOXO1 in BCR–ABL1-independent tyrosine kinase inhibitor resistance in chronic myeloid leukemia. Leukemia 30(7), 1493–1501 (2016).Crossref, Medline, CAS, Google Scholar13. Prost S, Relouzat F, Spentchian M et al. Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists. Nature 525(7569), 380–383 (2015).Crossref, Medline, CAS, Google Scholar14. Schoepf AM, Salcher S, Obexer P, Gust R. 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Des. 20(5), 793–807 (2014).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 12, No. 23 Follow us on social media for the latest updates Metrics Downloaded 115 times History Received 22 August 2020 Accepted 3 September 2020 Published online 24 November 2020 Published in print December 2020 Information© 2020 Newlands PressKeywordscancer stem cells (CSCs)cell death modulatorschronic myeloid leukemia (CML)sensitizerstherapy resistancetyrosine kinase inhibitor (TKI)Financial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.No writing assistance was utilized in the production of this manuscript.PDF download
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