亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Cancer-associated fibroblasts and the related Runt-related transcription factor 2 (RUNX2) promote bladder cancer progression

生物 膀胱癌 癌相关成纤维细胞 肿瘤进展 运行x2 癌症研究 肿瘤微环境 转录因子 癌症 转移 细胞外基质 癌变 病理 基因 细胞生物学 医学 遗传学 肿瘤细胞
作者
Bitian Liu,Shen Pan,Junlong Liu,Chuize Kong
出处
期刊:Gene [Elsevier]
卷期号:775: 145451-145451 被引量:25
标识
DOI:10.1016/j.gene.2021.145451
摘要

Bladder urothelial cancer (BLCA) has a high incidence worldwide. Cancer-associated fibroblasts (CAFs) in the tumor microenvironment are gradually recognized to play an important role in the occurrence and progression of cancer. However, the research on BLCA CAFs is still in its infancy, and the CAFs related genes are still unclear. We used the identified BLCA-specific CAFs gene signature in our previous work to calculate the CAFs infiltration score of the sample. Furthermore, we used data from multiple public databases to prove that CAFs high infiltration is associated with tumor progression and poor prognosis. In order to select the powerful genes in BLCA that are related to CAFs infiltration and affect prognosis, we chose transcription factors as the research object, and finally defined RUNX2 as the candidate gene for functional verification. In the immunohistochemical images, tissues with higher RUNX2 expression also had deeper staining of CAFs markers. We used public databases and collected specimens to prove that RUNX2 is overexpressed at the mRNA and protein levels in BLCA tissues. Through functional enrichment analysis, RUNX2 is mainly related to epithelialmesenchymal transition and extracellular matrix. Finally, we knocked down RUNX2 in vitro and observed a significant decrease in the metastasis and proliferation ability. In conclusion, high infiltration of CAFs is associated with tumor progression and poor prognosis in BLCA. RUNX2 is a transcription factor related to CAFs, which is overexpressed in bladder cancer and affects the prognosis. RUNX2 is a potential marker relating CAFs and therapy target in BLCA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
6秒前
10秒前
不倦应助科研通管家采纳,获得10
10秒前
JamesPei应助科研通管家采纳,获得10
10秒前
李爱国应助科研通管家采纳,获得10
10秒前
科研通AI2S应助科研通管家采纳,获得10
11秒前
Jasper应助科研通管家采纳,获得10
11秒前
sunny发布了新的文献求助10
11秒前
隐形曼青应助孙嘉遇采纳,获得10
12秒前
ronnie147完成签到 ,获得积分10
16秒前
Hello应助多多采纳,获得10
18秒前
SciGPT应助不样钓鱼采纳,获得10
27秒前
某人金完成签到,获得积分10
32秒前
Hi完成签到 ,获得积分10
36秒前
科研通AI5应助mxx采纳,获得10
39秒前
40秒前
shl发布了新的文献求助10
45秒前
50秒前
CodeCraft应助shl采纳,获得10
50秒前
mxx完成签到,获得积分20
52秒前
55秒前
mxx发布了新的文献求助10
55秒前
彬彬完成签到,获得积分10
58秒前
麻瓜完成签到,获得积分10
1分钟前
多多发布了新的文献求助10
1分钟前
科目三应助YISAN采纳,获得10
1分钟前
自然完成签到,获得积分10
1分钟前
糖伯虎完成签到 ,获得积分10
1分钟前
NexusExplorer应助vv采纳,获得10
1分钟前
Owen应助KSung采纳,获得10
1分钟前
1分钟前
彬彬发布了新的文献求助10
1分钟前
1分钟前
1分钟前
bdhdbb发布了新的文献求助10
1分钟前
KSung发布了新的文献求助10
1分钟前
easoncao完成签到,获得积分10
1分钟前
不样钓鱼发布了新的文献求助10
1分钟前
1分钟前
不样钓鱼完成签到,获得积分10
1分钟前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Conference Record, IAS Annual Meeting 1977 820
England and the Discovery of America, 1481-1620 600
Fault identification method of electrical automation distribution equipment in distribution networks based on neural network 560
Teaching language in context (Third edition) by Derewianka, Beverly; Jones, Pauline 550
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3580342
求助须知:如何正确求助?哪些是违规求助? 3149859
关于积分的说明 9479254
捐赠科研通 2851350
什么是DOI,文献DOI怎么找? 1567740
邀请新用户注册赠送积分活动 734241
科研通“疑难数据库(出版商)”最低求助积分说明 720549