ALDH2
ADH1B型
医学
结直肠癌
优势比
逻辑回归
内科学
病例对照研究
肿瘤科
癌症
等位基因
环境卫生
遗传学
生物
基因
生物化学
脱氢酶
酶
支链α-酮酸脱氢酶复合物
作者
Ju Eun Seol,Jeongseon Kim,Bong-Hwa Lee,Dae–Yong Hwang,Jinyoung Jeong,Hun Jae Lee,Yoon‐Ok Ahn,Jung Eun Lee,Dong-Hyun Kim
出处
期刊:Public Health Nutrition
[Cambridge University Press]
日期:2020-03-30
卷期号:24 (4): 677-684
被引量:12
标识
DOI:10.1017/s136898001900452x
摘要
Abstract Objective: There is limited evidence on the interaction by alcohol dehydrogenase 2 ( ADH1B ) (rs1229984) and aldehyde dehydrogenase 2 ( ALDH2 ) (rs671) regarding the associations of alcohol and a methyl diet (low folate and high alcohol intake) with cancer risk, partly because of rare polymorphisms in Western populations. Design: In a case–control study, we estimated the ORs and 95 % CIs to evaluate the associations of ADH1B and ALDH2 genotypes with colorectal cancer (CRC) and the joint association between methyl diets and ADH1B and ALDH2 polymorphisms with CRC risk using logistic regression models. Setting: A hospital-based case–control study. Participants: In total, 1001 CRC cases and 899 cancer-free controls admitted to two university hospitals. Results: We found that alcohol intake increased the risk of CRC; OR (95 % CI) was 2·02 (1·41, 2·87) for ≥60 g/d drinkers compared with non-drinkers ( P trend < 0·001). The associations for two polymorphisms with CRC were not statistically significant. However, we found a potential interaction of ALDH2 with methyl diets and CRC. We observed a 9·08-fold (95 % CI 1·93, 42·60) higher risk of CRC for low-methyl diets compared with high-methyl diets among individuals with an A allele of ALDH2 , but the association was not apparent among those with ALDH2 GG ( P interaction = 0·02). Conclusions: Our data support the evidence that gene–methyl diet interactions may be involved in CRC risk in East Asian populations, showing that a low-methyl diet increased the risk of CRC among individuals with an A allele of ALDH2 .
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