褐藻糖胶
酪氨酸酶
化学
抗氧化剂
多糖
生物化学
硫酸化
酶
食品科学
作者
Qianru Chen,Lingyun Kou,Feng-Wu Wang,Ying Wang
标识
DOI:10.1016/j.carbpol.2019.115211
摘要
Fucoidan from Laminaria japonica is a kind of sulfate polysaccharide with high molecular weight (MW) and broad bioactivities. This study was performed to investigate the relationship between MW and whitening activity of fucoidan and to exploit a novel functional ingredient for whitening cosmetics. High sulfate content fucoidan was enzymic degraded by Flavobacterium RC2-3 produced fucoidanase. Two hours were enough for the enzyme degradation to achieve degraded fucoidan with favorable tyrosinase inhibitory ability. The whitening activity of different MW fucoidan fractions were evaluated by their tyrosinase inhibitory ability, antioxidant activity and cellular melanogenesis inhibitory ability. Results showed that in the MW range above 5 kDa, the smaller MW of fucoidan were related to the better whitening activity. The fucoidan fraction with the MW between 5–10 kDa, presented the best tyrosinase inhibitory activity (62.0%), antioxidant activity (48.3%) and excellent anti-melanogenesis ability in B16 cells, which could be applied as the whitening factor in cosmetics development.
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