The association among severity of sarcopenia, salivation and salivary oxidative stress marker in stable COPD

In both COPD and periodontal disease (PD), systemic chronic inflammation, oxidative stress, and sarcopenia are highly comorbid. Preservation of chewing power and salivation in the elderly COPD are thought to be important for nutrition, oral hygiene and prevention of aspiration pneumonia. COPD and PD could be mutually involved in the progression of the disease condition with cigarette smoking as a common risk factor. We examined whether salivation, systemic inflammatory markers, salivary oxidative stress markers, sarcopenia and PD are related to COPD. The subjects were stable COPD (N=70, mean age 74). Patients with systemic inflammation, malignancy, current smokers and ICS users were excluded. Salivation and levels of some serum and salivary biomarkers were measured by ELISA. For the parameters of sarcopenia, the muscle mass by the bioelectrical impedance method and the grip strength were used. The mean CRP level of each GOLD stage group was shown significant differences between stage groups, respectively. The CRP level was correlated negatively with the number of residual teeth and positively with the plaque control ratio. Saliva MMP-9 and PGE2 levels were had significantly difference between severity of PD. Saliva 8-OHdG, IL-6 levels were more related to respiratory function and CAT score than the severity of PD. The amount of salivation was correlated positively with the grip strength, saliva 8-OHdG level showed a negative correlation with muscle mass and grip strength. Measurement of salivation and salivary oxidative stress in COPD may be useful for prediction of sarcopenia and mastication ability.