A novel rabbit thromboembolic occlusion model

医学 主动脉 闭塞 颈总动脉 颈内动脉 主动脉分叉 血运重建 解剖 心脏病学 内科学 颈动脉 心肌梗塞
作者
Yong Hong Ding,Seán Fitzgerald,Yang Liu,Daying Dai,Daniel R. Jakaitis,Karen Doyle,Waleed Brinjikji,David F. Kallmes,Luis Savastano,Ramanathan Kadirvel
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:13 (11): 1040-1043 被引量:3
标识
DOI:10.1136/neurintsurg-2020-017073
摘要

To develop a preclinical thromboembolic occlusion model for studying revascularization strategies.Clot analog with barium sulfate was injected into the distal aorta in 9 New Zealand white rabbits. The situation of aorta occlusion was compared among fibrin-rich (n=4), red blood cell (RBC)-rich (n=3), and whole blood clot analogs (n=2) using digital subtraction angiography. Arterial geometries, histologic features and circumferential stretch of the distal aorta in rabbits were compared with the common carotid artery in swine and the distal internal carotid artery (ICA) in humans. Aspiration thrombectomy and mechanical thrombectomy using a stent retriever were performed in two rabbits.The aortic bifurcation was occluded after a single delivery of clot in 4 cases. It was occluded after the second clot injection in the 5 remaining rabbits. Fragmentation of RBC-rich clots occurred during clot injection in 2 cases. The mean diameters of the distal aorta and right common iliac artery in rabbits were 3.7±0.4 and 2.8±0.3 mm, respectively; the mean diameters of human ICA, and first and second segments of the middle cerebral artery (M1, M2) were 3.6±0.4, 3.1±0.4, and 2.4±0.4 mm, respectively. Arterial revascularization was achieved in both rabbits. Geometric, mechanical and histological factors of the distal aorta in rabbit were more close to human distal ICA than swine carotid artery.Arterial occlusion can be achieved at the aortic bifurcation in rabbits, which is comparable to human ICA bifurcation. This thrombectomy model has the potential to be used for testing of thrombectomy devices.
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