已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

A novel rabbit thromboembolic occlusion model

医学 主动脉 闭塞 颈总动脉 颈内动脉 主动脉分叉 血运重建 解剖 心脏病学 内科学 颈动脉 心肌梗塞
作者
Yong Hong Ding,Seán Fitzgerald,Yang Liu,Daying Dai,Daniel R. Jakaitis,Karen Doyle,Waleed Brinjikji,David F. Kallmes,Luis Savastano,Ramanathan Kadirvel
出处
期刊:Journal of NeuroInterventional Surgery [BMJ]
卷期号:13 (11): 1040-1043 被引量:3
标识
DOI:10.1136/neurintsurg-2020-017073
摘要

To develop a preclinical thromboembolic occlusion model for studying revascularization strategies.Clot analog with barium sulfate was injected into the distal aorta in 9 New Zealand white rabbits. The situation of aorta occlusion was compared among fibrin-rich (n=4), red blood cell (RBC)-rich (n=3), and whole blood clot analogs (n=2) using digital subtraction angiography. Arterial geometries, histologic features and circumferential stretch of the distal aorta in rabbits were compared with the common carotid artery in swine and the distal internal carotid artery (ICA) in humans. Aspiration thrombectomy and mechanical thrombectomy using a stent retriever were performed in two rabbits.The aortic bifurcation was occluded after a single delivery of clot in 4 cases. It was occluded after the second clot injection in the 5 remaining rabbits. Fragmentation of RBC-rich clots occurred during clot injection in 2 cases. The mean diameters of the distal aorta and right common iliac artery in rabbits were 3.7±0.4 and 2.8±0.3 mm, respectively; the mean diameters of human ICA, and first and second segments of the middle cerebral artery (M1, M2) were 3.6±0.4, 3.1±0.4, and 2.4±0.4 mm, respectively. Arterial revascularization was achieved in both rabbits. Geometric, mechanical and histological factors of the distal aorta in rabbit were more close to human distal ICA than swine carotid artery.Arterial occlusion can be achieved at the aortic bifurcation in rabbits, which is comparable to human ICA bifurcation. This thrombectomy model has the potential to be used for testing of thrombectomy devices.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
一丢丢完成签到 ,获得积分10
3秒前
Li发布了新的文献求助10
5秒前
5秒前
livingroom完成签到,获得积分10
6秒前
卿卿完成签到,获得积分10
7秒前
跳跃太清完成签到 ,获得积分10
9秒前
Karol发布了新的文献求助10
11秒前
mengliu完成签到,获得积分10
14秒前
李健的粉丝团团长应助Li采纳,获得10
17秒前
NexusExplorer应助zhouleiwang采纳,获得10
20秒前
云上人完成签到 ,获得积分10
21秒前
wxh发布了新的文献求助10
22秒前
suxili完成签到 ,获得积分10
24秒前
25秒前
大观天下发布了新的文献求助10
28秒前
熊二浪完成签到,获得积分10
30秒前
Owen应助读书的时候采纳,获得10
32秒前
大模型应助wxh采纳,获得10
32秒前
34秒前
威武灵阳完成签到,获得积分10
35秒前
sunnn完成签到 ,获得积分10
35秒前
薯条一克完成签到 ,获得积分10
38秒前
郗妫完成签到,获得积分10
39秒前
深山何处钟声鸣完成签到 ,获得积分0
40秒前
欢呼的世立完成签到 ,获得积分10
40秒前
平常的羊完成签到 ,获得积分10
47秒前
未夕晴完成签到,获得积分10
49秒前
Atropine完成签到 ,获得积分10
52秒前
53秒前
53秒前
54秒前
明亮访烟完成签到 ,获得积分10
56秒前
zhouleiwang发布了新的文献求助10
57秒前
58秒前
荔枝完成签到 ,获得积分10
58秒前
忐忑的雪糕完成签到 ,获得积分10
1分钟前
Cong发布了新的文献求助10
1分钟前
SYLH应助小刘采纳,获得10
1分钟前
jojo完成签到 ,获得积分10
1分钟前
1分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989989
求助须知:如何正确求助?哪些是违规求助? 3532034
关于积分的说明 11256053
捐赠科研通 3270900
什么是DOI,文献DOI怎么找? 1805105
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809216