Body composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis

医学 骨关节炎 体质指数 队列 生活质量(医疗保健) 瘦体质量 物理疗法 内科学 后备箱 队列研究 病理 替代医学 护理部 生态学 体重 生物
作者
Anne‐Christine Rat,Jérémie Sellam,Bernard Mazières,Willy Ngueyon Sime,Patrice Fardellone,Françis Guillemin
出处
期刊:RMD Open [BMJ]
卷期号:11 (1): e004733-e004733
标识
DOI:10.1136/rmdopen-2024-004733
摘要

Objective The objective of this study was to analyse the association between body composition and changes in health-related quality of life (HRQoL) of patients followed for hip and knee osteoarthritis (OA). Methods Longitudinal data from the Knee and Hip OsteoArthritis Long-term Assessments (KHOALA) cohort, a multicentre cohort of 878 patients with symptomatic knee and/or hip OA, were used. The main outcome criteria were changes in patient-reported outcomes measures, the Study Short Form-36 (physical functioning, pain, mental health and vitality) and the OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL)(physical activity, pain and mental health). Body composition measurements were obtained from dual X-ray absorptiometry (DXA) scans in a subsample of 381 patients at year 3. Body composition variables were fat mass index (FMI (kg/m²)), percentage of fat mass, trunk to leg fat mass ratio (TFM/LFM) and skeletal muscle mass index (SMI (kg/m²)). To account for the correlation of repeated measures in each individual, GEE models were used. Results 290 patients with knee and 114 patients with hip OA were included in the analysis. In multivariate analysis, higher FMI at baseline and the presence of low lean mass were independently associated with worse physical functioning over time (β −0.02, 95% CI −0.03 to −0.01, p<0.0001 and β −0.21, 95% CI −0.02 to 0.02, p=0.02) for SF-36 dimensions. Higher TFM/LFM and SMI at baseline were associated with better mental health (β 0.09, 95% CI 0.02 to 0.15, p=0.008 and β 0.01, 95% CI 0.006 to 0.02, p<0.0001) and vitality. No association between body composition measures and pain remained in the multivariate analysis. Conclusions Higher FMI at baseline and the presence of low muscle mass were independently associated with worse physical function over 4 years, but not with pain. Higher TFM/LFM and SMI at baseline were associated with better mental health and vitality over time.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
hellokitty完成签到,获得积分10
5秒前
5秒前
小四发布了新的文献求助10
6秒前
12秒前
西瓜完成签到 ,获得积分10
12秒前
包容的忆灵完成签到 ,获得积分10
15秒前
高兴尔冬发布了新的文献求助10
17秒前
xiang完成签到 ,获得积分0
20秒前
小四完成签到,获得积分10
23秒前
FashionBoy应助slayers采纳,获得30
29秒前
量子星尘发布了新的文献求助10
32秒前
黑眼圈完成签到 ,获得积分10
38秒前
jia完成签到 ,获得积分10
39秒前
如履平川完成签到 ,获得积分10
40秒前
科目三应助忧伤的步美采纳,获得10
41秒前
大椒完成签到 ,获得积分10
44秒前
47秒前
49秒前
wisdom完成签到,获得积分10
49秒前
slayers发布了新的文献求助30
52秒前
53秒前
e746700020完成签到,获得积分10
54秒前
高兴尔冬完成签到,获得积分10
54秒前
李爱国应助不安的秋白采纳,获得10
56秒前
忧伤的步美完成签到,获得积分10
1分钟前
小西完成签到 ,获得积分10
1分钟前
郝老头完成签到,获得积分10
1分钟前
13313完成签到,获得积分10
1分钟前
su完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
量子星尘发布了新的文献求助10
1分钟前
slayers完成签到 ,获得积分10
1分钟前
1分钟前
知犯何逆完成签到,获得积分10
1分钟前
Krsky完成签到,获得积分10
1分钟前
ding应助不安的秋白采纳,获得10
1分钟前
1分钟前
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038039
求助须知:如何正确求助?哪些是违规求助? 3575756
关于积分的说明 11373782
捐赠科研通 3305574
什么是DOI,文献DOI怎么找? 1819239
邀请新用户注册赠送积分活动 892655
科研通“疑难数据库(出版商)”最低求助积分说明 815022