微塑料
斑马鱼
达尼奥
毒性
乙草胺
生物累积
氧化应激
生物
化学
杀虫剂
环境化学
生物化学
基因
生态学
有机化学
作者
Yangyang Wang,Yuexing Zhao,Hongwu Liang,Chaojie Ma,Naqi Cui,Huihui Cao,Wei Wei,Yu Liu
标识
DOI:10.1016/j.envpol.2023.122089
摘要
The co-exposure of microplastics (MPs) and other contaminants has aroused extensive attention, but the combined impacts of MPs and pesticides remain poorly understood. Acetochlor (ACT), a widely used chloroacetamide herbicide, has raised concerns for its potential bio-adverse effects. This study evaluated the influences of polyethylene microplastics (PE-MPs) for acute toxicity, bioaccumulation, and intestinal toxicity in zebrafish to ACT. We found that PE-MPs significantly enhanced ACT acute toxicity. Also, PE-MPs increased the accumulation of ACT in zebrafish and aggravate the oxidative stress damage of ACT in intestines. Exposure to PE-MPs or/and ACT causes mild damage to the gut tissue of zebrafish and altered gut microbial composition. In terms of gene transcription, ACT exposure triggered a significant increase in inflammatory response-related gene expressions in the intestines, while some pro-inflammatory factors were found to be inhibited by PE-MPs. This study provides a new perspective on the fate of MPs in the environment and on the assessment of the combined effects of MPs and pesticides on organisms.
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