Sleep patterns, genetic predisposition, and risk of chronic liver disease: A prospective study of 408,560 UK Biobank participants

医学 内科学 危险系数 脂肪肝 肝硬化 酒精性肝病 肝病 慢性肝病 比例危险模型 前瞻性队列研究 置信区间 疾病 胃肠病学
作者
Wenxiu Wang,Zhenhuang Zhuang,Zimin Song,Yimin Zhao,Tao Huang
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:352: 229-236 被引量:6
标识
DOI:10.1016/j.jad.2024.01.010
摘要

Little is known about the role that combined sleep behaviors play in the association with chronic liver disease (CLD) risk. We included 408,560 participants initially free of CLD from the UK Biobank. A healthy sleep pattern was defined by early chronotype, sleep duration of 7–8 h/day, no insomnia, no snoring, and no excessive daytime sleepiness. Cox regression models were used to examine the association of healthy sleep pattern with incident CLD and their interaction with PNPLA3 genetic risk. During a median 12.5 years of follow-up, we documented 10,915 incident all-cause CLD cases, including 388 viral hepatitis, 4782 non-alcoholic fatty liver disease (NAFLD), 1356 cirrhosis, 973 alcoholic liver disease, and 725 liver cancer cases. Compared to participants with a healthy sleep score of 0–1, the hazard ratio (HR) (95 % confidence interval [CI]) for those with a sleep score of 5 was 0.54 (0.49, 0.60) for CLD, 0.52 (0.30, 0.90) for viral hepatitis, 0.47 (0.41, 0.55) for NAFLD, 0.57 (0.43, 0.75) for cirrhosis, 0.32 (0.23, 0.44) for alcoholic liver disease, and 0.53 (0.37, 0.77) for liver cancer. Healthy sleep pattern and PNPLA3 genetic risk exerted significant additive effects on CLD risk (relative excess risk due to the interaction: 0.05; attributable proportion due to the interaction: 13 %). Measurement error was unavoidable for self-reported data on sleep behaviors. Our analyses provide evidence that healthy sleep pattern was inversely associated with the development of CLD, and participants with higher genetic risk were more likely to develop CLD when exposed to the unhealthy sleep pattern.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
龙行天下完成签到,获得积分10
刚刚
小蘑菇应助WN采纳,获得10
1秒前
2秒前
2秒前
东郭一斩完成签到,获得积分10
2秒前
量子星尘发布了新的文献求助10
2秒前
平安喜乐发布了新的文献求助10
3秒前
左孤容完成签到 ,获得积分10
3秒前
wanmiao12完成签到,获得积分10
5秒前
yu发布了新的文献求助10
6秒前
mmmmm完成签到,获得积分10
7秒前
洁净白容完成签到,获得积分10
7秒前
大个应助孟孟采纳,获得10
7秒前
小镇的废物完成签到,获得积分10
7秒前
柴郡喵完成签到,获得积分10
8秒前
SYLH应助小熊采纳,获得10
9秒前
妹妹发布了新的文献求助10
9秒前
9秒前
赘婿应助我必定发nature采纳,获得20
10秒前
Ava应助kofbird采纳,获得50
11秒前
zz完成签到,获得积分10
11秒前
星辰大海应助ybwei2008_163采纳,获得10
11秒前
13秒前
13秒前
QJYKKK完成签到,获得积分10
13秒前
composite66完成签到,获得积分10
13秒前
ccchao发布了新的文献求助30
14秒前
充电宝应助十三采纳,获得10
14秒前
大个应助橙橙橙采纳,获得10
14秒前
Dandanhuang完成签到,获得积分10
14秒前
FashionBoy应助孟孟采纳,获得30
16秒前
畅快的刚完成签到,获得积分10
18秒前
18秒前
xxxx完成签到,获得积分10
18秒前
vain发布了新的文献求助10
18秒前
李健应助芒果小鹌鹑采纳,获得10
18秒前
cc完成签到,获得积分10
19秒前
这个名字是不是独一无二完成签到,获得积分10
19秒前
颗粒完成签到,获得积分10
20秒前
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048