后代
小桶
海马结构
海马体
怀孕
生物
认知
基因
神经科学
遗传学
基因表达
基因本体论
作者
Jiang Chen,Ya‐Ping Zhang,Xuan Liu,Kang Li,Huanliang Liu,Wenqing Lai,Yue Shi,Zhuge Xi,Licheng Yan,Lei Tian,Bencheng Lin
标识
DOI:10.1080/26395940.2023.2292104
摘要
Nanoplastics, an emerging contaminant, pose risks to fetal neural development, transferring from mother to offspring via placenta and breast milk. Assessing these risks, hippocampal CA3 samples from nanopolystyrene-exposed rat offspring were proteomically analyzed. Findings revealed reduced expression of neural developmental proteins (KIF21A, STMN2, DMTN, DLG1) and increased inhibitory proteins (PZP, α-2M, FN1, SERPINA1, ALOX15) in the hippocampus. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis highlighted ferroptosis enrichment, validated by significantly expressed ALOX15 and TF proteins. These alterations suggest nanopolystyrene’s potential contribution to cognitive deficits and neurodevelopmental disorders, emphasizing its hazardous impact on neural development. This study provides novel insights into nanopolystyrene’s risks.
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