Legumain Regulates Regulatory T Cells in Hypertension

HomeCirculation ResearchVol. 134, No. 1Legumain Regulates Regulatory T Cells in Hypertension No AccessEditorialRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessEditorialRequest AccessFull TextLegumain Regulates Regulatory T Cells in Hypertension Matthew R. Alexander and David G. Harrison Matthew R. AlexanderMatthew R. Alexander Correspondence to: Matthew R. Alexander, MD, PhD, Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Ave, MRBIV P415D, Nashville, TN 37232. Email E-mail Address: [email protected] https://orcid.org/0000-0003-4739-7204 Department of Medicine, Division of Clinical Pharmacology, and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN. Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN. and David G. HarrisonDavid G. Harrison https://orcid.org/0000-0001-9363-6451 Department of Medicine, Division of Clinical Pharmacology, and Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN. Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, TN. Vanderbilt Institute for Infection, Immunology, and Inflammation, Nashville, TN. Originally published4 Jan 2024https://doi.org/10.1161/CIRCRESAHA.123.324010Circulation Research. 2024;134:30–32This article is a commentary on the followingCD4+ T-Cell Legumain Deficiency Attenuates Hypertensive Damage via Preservation of TRAF6FootnotesFor Sources of Funding and Disclosures, see page 32.The opinions expressed in this article are not necessarily those of the editors or of the American Heart Association.Correspondence to: Matthew R. Alexander, MD, PhD, Department of Medicine, Division of Clinical Pharmacology, Vanderbilt University Medical Center, 2213 Garland Ave, MRBIV P415D, Nashville, TN 37232. Email matt.alexander@vumc.orgREFERENCES1. He Y, Zou P, Lu J, Lu Y, Yuan S, Zheng X, Liu J, Zeng C, Liu L, Tang L, et al. CD4+ T cell legumain deficiency attenuates hypertensive damage via preservation of TRAF6.Circ Res. 2024; 134:9–29. doi: 10.1161/CIRCRESAHA.123.322835LinkGoogle Scholar2. Solberg R, Lunde NN, Forbord KM, Okla M, Kassem M, Jafari A. 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Freeley S, Cardone J, Günther SC, West EE, Reinheckel T, Watts C, Kemper C, Kolev MV. Asparaginyl endopeptidase (legumain) supports human th1 induction via cathepsin L-mediated intracellular C3 activation.Front Immunol. 2018; 9:2449. doi: 10.3389/fimmu.2018.02449CrossrefMedlineGoogle Scholar14. Li N, Liu C, Ma G, Tseng Y, Pan D, Chen J, Li F, Zeng X, Luo T, Chen S. Asparaginyl endopeptidase may promote liver sinusoidal endothelial cell angiogenesis via PI3K/Akt pathway.Rev Esp Enferm Dig. 2019; 111:214–222. doi: 10.17235/reed.2018.5709/2018CrossrefMedlineGoogle Scholar15. Meng X, Yang J, Dong M, Zhang K, Tu E, Gao Q, Chen W, Zhang C, Zhang Y. Regulatory T cells in cardiovascular diseases.Nat Rev Cardiol. 2015; 13:167–179. doi: 10.1038/nrcardio.2015.169CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. 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Circulation Research. 2024;134:9-29 January 5, 2024Vol 134, Issue 1 Advertisement Article InformationMetrics © 2023 American Heart Association, Inc.https://doi.org/10.1161/CIRCRESAHA.123.324010PMID: 38175912 Originally publishedJanuary 4, 2024 KeywordsEditorialshypertensioninflammationT-lymphocytesT lymphocytes, regulatoryPDF download Advertisement