生物
RNA编辑
RNA沉默
转录组
计算生物学
核糖核酸
功能(生物学)
阿达尔
先天免疫系统
肌苷
RNA干扰
遗传学
免疫系统
基因
腺苷
基因表达
生物化学
作者
Erez Y. Levanon,Roni Cohen‐Fultheim,Eli Eisenberg
标识
DOI:10.1016/j.tig.2023.12.002
摘要
Recent studies have underscored the pivotal role of adenosine-to-inosine RNA editing, catalyzed by ADAR1, in suppressing innate immune interferon responses triggered by cellular double-stranded RNA (dsRNA). However, the specific ADAR1 editing targets crucial for this regulatory function remain elusive. We review analyses of transcriptome-wide ADAR1 editing patterns and their evolutionary dynamics, which offer valuable insights into this unresolved query. The growing appreciation of the significance of immunogenic dsRNAs and their editing in inflammatory and autoimmune diseases and cancer calls for a more comprehensive understanding of dsRNA immunogenicity, which may promote our understanding of these diseases and open doors to therapeutic avenues.
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