催化作用
电泳剂
化学
组合化学
镍
试剂
芳基
表面改性
光催化
氢键
对映选择合成
有机化学
光化学
分子
光催化
烷基
物理化学
作者
Sergio Cuesta‐Galisteo,Johannes Schörgenhumer,Cédric Hervieu,Cristina Nevado
标识
DOI:10.1002/anie.202313717
摘要
Radical‐mediated Hydrogen Atom Abstraction of Csp3‐H bonds has become a powerful tool for the asymmetric functionalization of organic feedstocks. Here, we present an asymmetric synthesis of α‐aryl amides via carbamoylation of alkylarenes with isocyanates as electrophiles. The synergistic combination of a photoredox and a chiral nickel‐catalyst, enables the use of readily available and neutral reagents under mild reaction conditions and provides straightforward access to pharmacologically relevant motifs in enantiomerically pure form.
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