心脏毒性
阿霉素
医学
药理学
NADPH氧化酶
迷走神经电刺激
细胞凋亡
氧化应激
炎症
刺激
癌症研究
内科学
生物
迷走神经
化疗
生物化学
作者
Mengjie Xie,Feng-Biao Guo,Lingpeng Song,Wuping Tan,Xu Han,Saiting Xu,Xujun Li,Yijun Wang,Yueyi Wang,Liping Zhou,Xin Zhou,Hong Jiang,Lilei Yu
出处
期刊:iScience
[Elsevier]
日期:2024-02-01
卷期号:: 109163-109163
标识
DOI:10.1016/j.isci.2024.109163
摘要
Doxorubicin (Dox) poses a considerable threat to patients owing to its cardiotoxicity, thus limiting its clinical utility. Optimal cardioprotective intervention strategies are needed to suppress tumor growth but also minimize cardiac side effects. Here, we showed that tragus vagus nerve stimulation (tVNS) improved the imbalanced autonomic tone, ameliorated impaired cardiac function and fibrosis, attenuated myocyte apoptosis, and mitochondrial dysfunction compared to those in the Dox group. The beneficial effects were attenuated by methyllycaconitine citrate (MLA). The transcript profile revealed that there were 312 differentially expressed genes and the protection of tVNS and retardation of MLA were related to inflammatory response and NADPH oxidase activity. In addition, tVNS synergizing with Dox inhibited tumor growth and lung metastasis and promoted apoptosis of tumor cells in an anti-tumor immunity manner. These results indicated that non-invasive neuromodulation can play a dual role in preventing Dox-induced cardiotoxicity and suppressing tumor growth through inflammation and oxidative stress.
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