细胞外基质
蛋白多糖
转移
肿瘤微环境
黑色素瘤
癌症
生物
医学
细胞生物学
内科学
肿瘤细胞
癌症研究
出处
期刊:Nature Aging
日期:2024-03-12
卷期号:4 (3): 287-288
标识
DOI:10.1038/s43587-024-00574-7
摘要
The extracellular matrix is an essential component of the tumor microenvironment and affects cancer progression. Weeraratna and colleagues have now uncovered that age-related reductions in the level of hyaluronan and proteoglycan link protein 1 (HAPLN1) stimulate neoangiogenesis and compromise the vascular integrity of intratumoral blood vessels. These biological modifications converge to fuel distant melanoma metastasis.
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