化学
阿托品
全合成
组合化学
亲核芳香族取代
立体化学
联动装置(软件)
有机化学
生物化学
亲核取代
基因
作者
Longhui Yu,Yuuya Nagata,Hakobu Nakamura
摘要
A short, atroposelective synthesis of cihunamide B (1) is reported. The feature of this report is the decagram-scale SNAr reaction of l-tryptophan derivatives, followed by atroposelective Larock macrocyclization. This strategy allowed the construction of a Trp-Trp cross-linkage with unprecedented atropisomerism. The atroposelectivity of this Larock macrocyclization has been investigated through a combination of experimental and computational chemistry, yielding detailed insights into the synthesis of biaryl linkages. It also enabled the concise synthesis of cihunamide B (1), which is expected to be a potential antibacterial agent.
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