Piwi相互作用RNA
拉西尔纳
生物
阿尔戈瑙特
小RNA
核糖核酸
生殖系
计算生物学
遗传学
小RNA
生物信息学
RNA干扰
基因
作者
Yizhu Yao,Yaozhe Li,Xiayan Zhu,Chengguang Zhao,Lehe Yang,Xiaoying Huang,Liangxing Wang
标识
DOI:10.1186/s12931-023-02367-9
摘要
Abstract PIWI-interacting RNA (piRNA) is a class of recently discovered small non-coding RNA molecules with a length of 18–33 nt that interacts with the PIWI protein to form the piRNA/PIWI complex. The PIWI family is a subfamily of Argonaute (AGO) proteins that also contain the AGO family which bind to microRNA (miRNA). Recently studies indicate that piRNAs are not specific to in the mammalian germline, they are also expressed in a tissue-specific manner in a variety of human tissues and participated in various of diseases, such as cardiovascular, neurological, and urinary tract diseases, and are especially prevalent in malignant tumors in these systems. However, the functions and abnormal expression of piRNAs in respiratory tract diseases and their underlying mechanisms remain incompletely understood. In this review, we discuss current studies summarizing the biogenetic processes, functions, and emerging roles of piRNAs in respiratory tract diseases, providing a reference value for future piRNA research.
科研通智能强力驱动
Strongly Powered by AbleSci AI