自闭症谱系障碍
磁刺激
心理学
听力学
模仿
适应行为量表
自闭症
视频建模
发展心理学
医学
神经科学
刺激
教育学
教学方法
建模
作者
Jirapimon Kaokhieo,Jarugool Tretriluxana,Pakaratee Chaiyawat,Vorasith Siripornpanich,Kannika Permpoonputtana,Suradej Tretriluxana,Ampika Nanbancha
出处
期刊:Brain Research
[Elsevier]
日期:2023-01-23
卷期号:1804: 148258-148258
被引量:8
标识
DOI:10.1016/j.brainres.2023.148258
摘要
To investigate the feasibility of a combined high-frequency rTMS (HF-rTMS) with action observation and execution (AOE) on social interaction and communication in children with Autistic Spectrum Disorder (ASD).Fifteen children underwent 10 sessions of 5-Hz HF-rTMS on the right inferior frontal gyrus combined with AOE. An experimental group received the real HF-rTMS while the control group received the sham one. For the AOE protocol, they were instructed to watch and imitate a video showing the procedure, including reaching and grasping tasks, gustatory tasks, and facial expressions. Their behavioural outcomes were evaluated using the Vineland Adaptive Behaviour Scale (VABS) and electroencephalograms (EEGs) recorded at three time points: baseline, immediately after each treatment, and at the 1-week follow-up after the 10th treatment.There were increased VABS subitem scores in the experimental group, including the receptive, expressive, domestic, and community scores but no such increase was observed in the control group. For the EEG, the beta rhythm at C3 and C4 increased in the experimental group. Additionally, positive correlations were observed between changes in the scores for the expressive subitem and changes in the beta rhythm on the C4 electrode at baseline and immediately after treatment in the experimental group. The control group showed no significant differences in any items for both observation and imitation times.Ten sessions of HF-rTMS combined with AOE could improve both the subitems of communication and daily living skills domain in children aged 7-12 years with ASD. Although it is still inconclusive, this behavioural improvement may be partly attributable to increased cortical activity, as evidenced by beta rhythms.
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