Endoscopic retrograde cholangiopancreatography (ERCP) in patients with surgically altered anatomy is intrinsically challenging [1]. Pooled rates of technical success, clinical success, and adverse events with balloon-assisted ERCP are reported to be 71.4 %, 58.7 %, and 8.4 %, respectively [2]. We report a case where we successfully performed novel motorized spiral enteroscopy (NMSE)-assisted ERCP in a patient with surgically altered anatomy.