Direct economic burden 1 year postoperation in Chinese adult patients with chronic rhinosinusitis with nasal polyps

ABSTRACTBackground Chronic rhinosinusitis with nasal polyps (CRSwNP) remains a common and challenging clinical entity, and its economic burden has not been well described in China thus far.Methods A total of 101 CRSwNP patients who underwent endoscopic sinus surgery were included to investigate direct costs in the first year post-surgery. Costs for outpatient visits, medication use, and examination costs were obtained from the Hospital Information System, and differences were compared between subgroups. Multiple linear regression analysis was adopted to investigate the main influencing factors on annual total direct costs for CRSwNP patients.Results Ninety-two subjects completed the study. The individual mean total direct cost for a CRSwNP patient 1 year post-surgery was $742.4. The largest contributors were pharmacy costs ($580.2), followed by examination costs ($108.1) and outpatient visits ($54.1). Total direct costs were higher in subgroups of patients with uncontrolled clinical status, asthma comorbidity, and eosinophilic CRSwNP compared to their counterparts. The main influencing factors were clinical control status (P = 0.016) and asthma comorbidity (P = 0.035).Conclusions The individual mean total direct cost of CRSwNP in 1-year post-surgery was $742.4. Clinical control status and asthma comorbidity influence these costs and are therefore important in guiding health resources allocation for CRSwNP management.KEYWORDS: Chronic rhinosinusitisnasal polypsdirect costseconomic burdenpostoperation Declaration of interestThe authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.Reviewer disclosuresPeer reviewers on this manuscript have no relevant financial or other relationships to disclose.Author contributionsX Li and J Li wrote the manuscript. X Li, W She, and X Xu collected data. C Wang and Y Zhang analyzed the data. Y Zhang and L Zhang designed the study and revised the manuscript accordingly. All authors read and approved the final manuscript for publication.Statement of ethicsThe study protocol was approved by the Ethics Committee of Beijing Tongren Hospital, and all participants provided written informed consent prior to enrollment in the study.Data availability statementThe data supporting the findings of this study are available upon reasonable request from the corresponding author. The data are not publicly available because of privacy or ethical restrictions.Additional informationFundingThis work was supported by grants from national key R&D program of China (2022YFC2504100), the program for the Changjiang scholars and innovative research team (IRT13082), CAMS innovation fund for medical sciences (2019-I2M-5-022), Capital’s funds for health improvement and research (2022-1-1091), Natural Science Foundation of China (81970849, 82071022 and 82271141) and Beijing Municipal Science & Technology Commission (Z211100002921060).