PEAK EXPIRATORY FLOW AND MOTORIC COGNITIVE RISK SYNDROME

SESSION TITLE: Pulmonary Rehabilitation Posters SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2023 12:00 pm - 12:45 pm PURPOSE: The current literature suggests a relationship among respiratory, physical, and cognitive function. Peak expiratory flow (PEF) is a measure of respiratory function. Motoric cognitive risk (MCR) syndrome is characterized by slow gait speed and subjective memory impairment, and is associated with a higher risk of dementia, as well as falls, disability, and mortality. However, the connection between PEF and MCR syndrome is unknown and investigated in this study. METHODS: This study examined older adults ≥65 years of age from the 2011 National Health and Aging Trends Study (NHATS). Participants completed structured questionnaires and physical assessments. Raw PEF values were converted to standardized residuals (SR) as done in past studies based on age, sex, and height, and compared with a healthy subsample of participants without a history of heart disease, heart attack, stroke, lung disease, regular smoking, or cancer. PEF SR percentile groups were then created: <10, 10-30, 30-50, 50-80, and ≥80. MCR syndrome was defined based on previously published definitions. Multivariable logistic regression adjusting for age, sex, body mass index, education, heart disease, heart attack, hypertension, diabetes, stroke, lung disease, regular smoking, arthritis, cancer, depression, and physical activity level tested the association between PEF SR and MCR syndrome. RESULTS: There were 5674 included participants with MCR syndrome prevalence of 4.7%. After multivariable adjustment, one standard deviation below the mean PEF SR was associated with 1.60 times higher odds of MCR syndrome (OR 1.60 [95% CI 1.39, 1.83], p<0.001). Compared with participants in the ≥80 PEF SR percentile reference group, those in the <10, 10-30, 30-50, and 50-80 percentile groups had 4.97, 2.54, 2.05, and 1.71 times higher odds of MCR syndrome, respectively (OR 4.97 [95% CI 2.91, 8.48], p<0.001; OR 2.54 [95% CI 1.53, 4.24], p<0.001; OR 2.05 [95% CI 1.21, 3.48], p=0.008; OR 1.71 [95% CI 1.02, 2.86], p=0.041, respectively). CONCLUSIONS: Lower PEF was significantly associated with higher odds of MCR syndrome. CLINICAL IMPLICATIONS: Future studies could examine whether interventions that improve PEF may reduce the risk of MCR syndrome and its sequelae, including dementia, falls, disability, and mortality. DISCLOSURES: No relevant relationships by Jim Ho No relevant relationships by Joe Verghese