上睑下垂
中性粒细胞胞外陷阱
肝细胞
坏死性下垂
cccDNA
程序性细胞死亡
免疫系统
医学
免疫学
癌症研究
细胞凋亡
炎症
乙型肝炎病毒
病毒
生物
炎症体
生物化学
乙型肝炎表面抗原
体外
作者
Qiang Zhao,Dong‐Ping Chen,Huadi Chen,Yingzhe Wang,Wei Shi,Yi-Tong Lu,Yi-Zheng Ren,Yuankai Wu,Yihua Pang,Hong Deng,Xiaoshun He,Dong‐Ming Kuang,Zhiyong Guo
标识
DOI:10.1097/hep.0000000000000868
摘要
HBV infection is a major etiology of acute-on-chronic liver failure (ACLF). At present, the pattern and regulation of hepatocyte death during HBV-ACLF progression are still undefined. Evaluating the mode of cell death and its inducers will provide new insights for developing therapeutic strategies targeting cell death. In this study, we aimed to elucidate whether and how immune landscapes trigger hepatocyte death and lead to the progression of HBV-related ACLF.
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