The protective effect of vitamin D supplementation as adjunctive therapy to antidepressants on brain structural and functional connectivity of patients with major depressive disorder: a randomized controlled trial

重性抑郁障碍 抗抑郁药 随机对照试验 医学 萧条(经济学) 焦虑 维生素D与神经学 内科学 磁共振弥散成像 精神科 心理学 磁共振成像 经济 宏观经济学 放射科 扁桃形结构
作者
Wenming Zhao,Dao‐min Zhu,Yuhao Shen,Yu Zhang,Tao Chen,Huanhuan Cai,Jiajia Zhu,Jiajia Zhu
出处
期刊:Psychological Medicine [Cambridge University Press]
卷期号:: 1-11
标识
DOI:10.1017/s0033291724000539
摘要

Growing evidence points to the pivotal role of vitamin D in the pathophysiology and treatment of major depressive disorder (MDD). However, there is a paucity of longitudinal research investigating the effects of vitamin D supplementation on the brain of MDD patients.We conducted a double-blind randomized controlled trial in 46 MDD patients, who were randomly allocated into either VD (antidepressant medication + vitamin D supplementation) or NVD (antidepressant medication + placebos) groups. Data from diffusion tensor imaging, resting-state functional MRI, serum vitamin D concentration, and clinical symptoms were obtained at baseline and after an average of 7 months of intervention.Both VD and NVD groups showed significant improvement in depression and anxiety symptoms but with no significant differences between the two groups. However, a greater increase in serum vitamin D concentration was found to be associated with greater improvement in depression and anxiety symptoms in VD group. More importantly, neuroimaging data demonstrated disrupted white matter integrity of right inferior fronto-occipital fasciculus along with decreased functional connectivity between right frontoparietal and medial visual networks after intervention in NVD group, but no changes in VD group.These findings suggest that vitamin D supplementation as adjunctive therapy to antidepressants may not only contribute to improvement in clinical symptoms but also help preserve brain structural and functional connectivity in MDD patients.
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