丁酰胆碱酯酶
乙酰胆碱酯酶
化学
苯并噻唑
胆碱酯酶
苯并咪唑
药理学
塔克林
加兰他明
胆碱能的
阿切
生物化学
酶
多奈哌齐
内科学
医学
有机化学
痴呆
疾病
作者
A. Saud,Krishnaraju Venkatesan,Ahmed Taha,K. Kalpana,V. Malarkodi,S Durgaramani,V. Vinoth Prabhu,Fatima Saleh,S Ezhilarasan
出处
期刊:PubMed
日期:2024-03-01
卷期号:28 (6): 2522-2537
标识
DOI:10.26355/eurrev_202403_35759
摘要
Alzheimer's disease (AD) is identified by neuropathological symptoms, and there is now no effective treatment for the condition. A lack of the brain neurotransmitter acetylcholine has been related to the etiology of Alzheimer's disease. Acetylcholinesterase is an enzyme that breaks down acetylcholine to an inactive form and causes the death of cholinergic neurons. Conventional treatments were used but had less effectiveness. Therefore, there is a crucial need to identify alternative compounds with potential anti-cholinesterase agents and minimal undesirable effects.
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