Biological evaluation of polycyclic chalcone based acrylamides in human MCF-7 and HeLa cancer cell lines

赫拉 查尔酮 MCF-7型 MTT法 化学 细胞培养 癌细胞 细胞毒性 宫颈癌 癌症研究 癌症 体外 立体化学 医学 生物化学 人体乳房 生物 内科学 遗传学
作者
Vijayakumar Gunasekaran,R. Yuvakkumar,G. Ravi,Surya Cholayil Palapetta,Harichandran Gurusamy
出处
期刊:Environmental Research [Elsevier]
卷期号:222: 115395-115395 被引量:7
标识
DOI:10.1016/j.envres.2023.115395
摘要

Breast and cervical cancer account for the majority of cancer-narrated fatalities among women worldwide, necessitating the development of novel, effective therapeutic ways to combat the disease. In this study, we synthesized 6-methoxy naphthalene and anthracene-based acrylamide chalcone (NBA and ABA) and evaluated its activity for cell multiplication inhibition against two cancer cell lines from humans such as MCF-7 (Human Breast) and HeLa (Cervical) by MTT assay. Physiochemical characterization, such as FT-IR and NMR analyses, validated the synthesized NBA and ABA. Both NBA and ABA have shown antiproliferative action against two cancer cell lines, each with IC50 values of 38.46 and 48.25 μg/mL for HeLa cells and 38.02 and 36.35 μg/mL for MCF-7 cell lines. The results suggest that these acrylamide chalcones for cancer therapy at the lowest concentration. NBA and ABA could prevent cervical and breast cancer in-vitro, and their anti-cancer activity was closely related to methoxy-substituted naphthalene, anthracene ring, α, β-unsaturated carbonyl and amide group. According to docking data, the NBA and ABA have dock scores ranging from -8.7 to -11.44 kcal/mol. The highest dock score for compound ABA was -11.58 kcal/mol and compound NBA was -10.77 kcal/mol with Braf (5VAM) binding site.
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