已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Glucose-Responsive Silk Fibroin Microneedles for Transdermal Delivery of Insulin

透皮 胰岛素 真皮 丝素 化学 肿胀 的 糖尿病 葡萄糖氧化酶 内科学 体内 透皮贴片 皮下注射 皮下组织 内分泌学 药理学 材料科学 医学 生物化学 外科 解剖 丝绸 生物 生物技术 复合材料
作者
Guohongfang Tan,Fujian Jiang,Tianshuo Jia,Zhenzhen Qi,Tieling Xing,Subhas C. Kundu,Shenzhou Lu
出处
期刊:Biomimetics [Multidisciplinary Digital Publishing Institute]
卷期号:8 (1): 50-50 被引量:9
标识
DOI:10.3390/biomimetics8010050
摘要

Microneedles (MNs) have attracted great interest as a drug delivery alternative to subcutaneous injections for treating diabetes mellitus. We report MNs prepared from polylysine-modified cationized silk fibroin (SF) for responsive transdermal insulin delivery. Scanning electron microscopy analysis of MNs’ appearance and morphology revealed that the MNs were well arranged and formed an array with 0.5 mm pitch, and the length of single MNs is approximately 430 μm. The average breaking force of an MN is above 1.25 N, which guarantees that it can pierce the skin quickly and reach the dermis. Cationized SF MNs are pH-responsive. MNs dissolution rate increases as pH decreases and the rate of insulin release are accelerated. The swelling rate reached 223% at pH = 4, while only 172% at pH = 9. After adding glucose oxidase, cationized SF MNs are glucose-responsive. As the glucose concentration increases, the pH inside the MNs decreases, the MNs’ pore size increases, and the insulin release rate accelerates. In vivo experiments demonstrated that in normal Sprague Dawley (SD) rats, the amount of insulin released within the SF MNs was significantly smaller than that in diabetic rats. Before feeding, the blood glucose (BG) of diabetic rats in the injection group decreased rapidly to 6.9 mmol/L, and the diabetic rats in the patch group gradually reduced to 11.7 mmol/L. After feeding, the BG of diabetic rats in the injection group increased rapidly to 33.1 mmol/L and decreased slowly, while the diabetic rats in the patch group increased first to 21.7 mmol/L and then decreased to 15.3 mmol/L at 6 h. This demonstrated that the insulin inside the microneedle was released as the blood glucose concentration increased. Cationized SF MNs are expected to replace subcutaneous injections of insulin as a new modality for diabetes treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
streamerz发布了新的文献求助30
1秒前
炙热雅琴发布了新的文献求助10
2秒前
Kz发布了新的文献求助10
4秒前
失眠的凡阳完成签到,获得积分10
4秒前
5秒前
科研通AI5应助炙热雅琴采纳,获得10
6秒前
6秒前
7秒前
7秒前
失眠朋友完成签到,获得积分10
9秒前
小开完成签到,获得积分10
9秒前
11秒前
11秒前
结实大白发布了新的文献求助10
11秒前
MH应助Kz采纳,获得30
12秒前
张立人发布了新的文献求助10
12秒前
12秒前
Azure完成签到,获得积分10
13秒前
桐桐应助喜悦香萱采纳,获得10
13秒前
13秒前
streamerz完成签到,获得积分10
14秒前
Orange应助zzzzzz采纳,获得10
15秒前
baobao发布了新的文献求助10
16秒前
木鱼发布了新的文献求助10
17秒前
善学以致用应助lxxy采纳,获得10
19秒前
李爱国应助茹茹采纳,获得10
19秒前
19秒前
19秒前
溏心蛋完成签到,获得积分20
22秒前
22秒前
今后应助禾火采纳,获得10
24秒前
24秒前
25秒前
lwh104完成签到,获得积分10
26秒前
木鱼完成签到,获得积分10
27秒前
share发布了新的文献求助10
29秒前
酷波er应助Pendragon采纳,获得10
31秒前
茹茹发布了新的文献求助10
31秒前
JW完成签到,获得积分10
32秒前
32秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Homolytic deamination of amino-alcohols 1000
Machine Learning Methods in Geoscience 1000
Resilience of a Nation: A History of the Military in Rwanda 888
Crystal Nonlinear Optics: with SNLO examples (Second Edition) 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3729012
求助须知:如何正确求助?哪些是违规求助? 3273991
关于积分的说明 9984175
捐赠科研通 2989275
什么是DOI,文献DOI怎么找? 1640280
邀请新用户注册赠送积分活动 779181
科研通“疑难数据库(出版商)”最低求助积分说明 748034