伤口愈合
趋化因子
血管生成
生物医学工程
纤维蛋白
单核细胞
四氯化碳
免疫系统
慢性伤口
渗透(战争)
医学
材料科学
免疫学
癌症研究
工程类
运筹学
作者
Hyunsik Choi,Bolam Kim,Sang Hoon Jeong,Tae Yeon Kim,Dong‐Pyo Kim,You‐Kwan Oh,Sei Kwang Hahn
出处
期刊:Small
[Wiley]
日期:2022-11-10
卷期号:19 (1)
被引量:43
标识
DOI:10.1002/smll.202204617
摘要
A variety of wound healing platforms have been proposed to alleviate the hypoxic condition and/or to modulate the immune responses for the treatment of chronic wounds in diabetes. However, these platforms with the passive diffusion of therapeutic agents through the blood clot result in the relatively low delivery efficiency into the deep wound site. Here, a microalgae-based biohybrid microrobot for accelerated diabetic wound healing is developed. The biohybrid microrobot autonomously moves at velocity of 33.3 µm s-1 and generates oxygen for the alleviation of hypoxic condition. In addition, the microrobot efficiently bound with inflammatory chemokines of interleukin-8 (IL-8) and monocyte chemoattractant protein-1 (MCP-1) for modulating the immune responses. The enhanced penetration of microrobot is corroborated by measuring fibrin clots in biomimetic wound using microfluidic devices and the enhanced retention of microrobot is confirmed in the real wounded mouse skin tissue. After deposition on the chronic wound in diabetic mice without wound dressing, the wounds treated with microrobots are completely healed after 9 days with the significant decrease of inflammatory cytokines below 31% of the control level and the upregulated angiogenesis above 20 times of CD31+ cells. These results confirm the feasibility of microrobots as a next-generation platform for diabetic wound healing.
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