In this paper, we study complete self-shrinkers in Euclidean space and prove that an nn-dimensional complete self-shrinker in Euclidean space Rn+1\mathbb {R}^{n+1} is isometric to either Rn\mathbb {R}^{n}, Sn(n)S^{n}(\sqrt {n}), or Sk(k)×Rn−kS^k (\sqrt {k})\times \mathbb {R}^{n-k}, 1≤k≤n−11\leq k\leq n-1, if the squared norm SS of the second fundamental form, f3f_3 are constant and SS satisfies S>1.83379S>1.83379. We should remark that the condition of polynomial volume growth is not assumed.