An Immediate Bacterial‐Responsive Supramolecular Thio‐Naphthalene Diimide: A Real‐Time NIR‐II Photothermal Anti‐bacterial

A new kind of supramolecular thio‐naphthalene diimide (SNDI) which can be immediately reduced as supramolecular radical anion by bacteria is reported. The introduction of thiocarbonyl effectively elevates the reduction potential of SNDI, largely increasing the bacteria‐response speed in hypoxia. It selectively distinguishes the bacteria with high and low reduction ability in real time. The host‐guest complexation of SNDI and cucurbit[7]uril can enhance radical anion quantum yield, ensuring intense NIR‐II absorption and realizing high photothermal conversion. The real‐time NIR‐II photothermal anti‐bacteria is successfully carried out. This development will enrich the design of bio‐responsive agent with promising future towards actual application.