Oxidative balance scores and depressive symptoms: Mediating effects of oxidative stress and inflammatory factors

氧化应激 全国健康与营养检查调查 调解 优势比 逻辑回归 医学 萧条(经济学) 病人健康调查表 联想(心理学) 抑郁症状 心理学 内科学 精神科 认知 人口 环境卫生 经济 心理治疗师 法学 宏观经济学 政治学
作者
Huiru Li,Lingling Song,Manqiu Cen,Xihang Fu,Xinxin Gao,Qianlin Zuo,Jing Wu
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:334: 205-212 被引量:63
标识
DOI:10.1016/j.jad.2023.04.134
摘要

Few studies have examined the combined effects of dietary and lifestyle factors on depressive symptoms. This study aimed to evaluate the association between oxidative balance score (OBS) and depressive symptoms and the underlying mechanisms. A total of 21,283 adults from the 2007 to 2018 National Health and Nutrition Examination Survey (NHANES) were included. Depressive symptoms were defined as a total score of ≥10 on the Patient's Health Questionnaire (PHQ-9). Twenty dietary and lifestyle factors were selected to calculate the OBS. Multivariable logistic regression analyses were used to evaluate the association between OBS and depression risk. Mediation analyses were conducted to explore the roles of oxidative stress and inflammatory markers. In multivariate model, a significant negative association was found between OBS and depression risk. Compared with those in OBS tertile 1, participants in tertile 3 had lower odds of developing depressive symptoms (OR:0.50; 95 % CI:0.40–0.62; P < 0.001). Restricted cubic splines showed a linear relationship between OBS and depression risk (P for nonlinearity = 0.67). Moreover, higher OBS was found to be associated with lower depression scores (β = −0.07; 95 % CI:−0.08, −0.05; P < 0.001). GGT concentrations and WBC counts mediated the association between OBS and depression scores by 5.72 % and 5.42 %, respectively (both P < 0.001), with a joint mediated effect of 10.77 % (P < 0.001). This study was a cross-sectional design making it difficult to infer a causal association. OBS is negatively associated with depression, which may be mediated in part by oxidative stress and inflammation.
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