光动力疗法
材料科学
血管闭塞
生物医学工程
荧光团
体内
血流
荧光
医学
病理
放射科
心脏病学
化学
光学
生物技术
有机化学
物理
生物
作者
Shuaishuai Bian,Xiuli Zheng,Weimin Liu,Jihao Li,Zekun Gao,Haohui Ren,Wenjun Zhang,Chun‐Sing Lee,Pengfei Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2023-04-26
卷期号:298: 122130-122130
被引量:9
标识
DOI:10.1016/j.biomaterials.2023.122130
摘要
Real-time monitoring vascular responses is crucial for evaluating the therapeutic effects of vascular-targeted photodynamic therapy (V-PDT). Herein, we developed a highly-stable and bright aggregation induced emission (AIE) fluorophore (PTPE3 NP) for dynamic fluorescence (FL) imaging of vascular dysfunction beyond 1300 nm window during V-PDT. The superior brightness (ϵmaxΦf>1000 nm ≈ 180.05 M-1 cm-1) and high resolution of PTPE3 NP affords not only high-clarity images of whole-body and local vasculature (hindlimbs, mesentery, and tumor) but also high-speed video imaging for tracking blood circulation process. By virtue of the NPs' prolonged blood circulation time (t1/2 ≈ 86.5 min) and excellent photo/chemical (pH, RONS) stability, mesenteric and tumor vascular dysfunction (thrombosis formation, vessel occlusion, and hemorrhage) can be successfully visualized during V-PDT by FL imaging for the first time. Furthermore, the reduction of blood flow velocity (BFV) can be monitored in real time for precisely evaluating efficacy of V-PDT. These provide a powerful approach for assessing vascular responses during V-PDT and promote the development of advanced fluorophores for biological imaging.
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