乳酸链球菌素
体内
黑色素瘤
化学
细胞凋亡
细胞毒性
药理学
癌细胞
抗菌剂
体外
癌症
癌症研究
生物
医学
生物化学
生物技术
内科学
有机化学
作者
Yousef Khazaei Monfared,Mohammad Mahmoudian,Fabrizio Caldera,Alberto Rubin Pedrazzo,Parvin Zakeri–Milani,Adrián Matencio,Francesco Trotta
标识
DOI:10.1016/j.jddst.2022.104065
摘要
Nisin, a small antimicrobial peptide, has been recently suggested as a novel potential therapeutic approach to treat cancer with no toxicity in humans. The current study used cross-linked-cyclodextrin nanosponges (CDNS) to load Nisin-Z to study the complexes' capacity against melanoma cancer in vitro and in vivo. In-vitro results showed that Nisin encapsulated in both CDNSs (PMDA and CDI-NSs) behaves as an effective antitumor agent by increasing the cytotoxicity and apoptosis against melanoma cancer cell lines (B16-F10). Furthermore, Nisin loaded on PMDA-NSs significantly inhibited the in-vivo growth of melanoma cancer in a mouse model compared to free Nisin-Z. Indeed, the weight and volume of melanoma tumors were outstandingly decreased in the group treated with Nisin-PMDA-NSs compared to free Nisin. On the other hand, the anti-cancer effects of Nisin related to its apoptosis and antioxidant activity were remarkably increased in complex with PMDA-NSs. Moreover, Nisin in nano-formulation led to a considerable decrease of CD31, an angiogenesis factor, expression in tumor tissues. Our findings suggest that incorporating Nisin into nanosponges as a safe carrier may improve Nisin's antitumor effect in melanoma cancer animal models.
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