单核细胞
医学
淋巴细胞
髓样
离体
免疫系统
免疫学
体外循环
免疫抑制
免疫耐受
细胞凋亡
T细胞
癌症研究
体内
生物
内科学
生物技术
生物化学
作者
Mathieu Lesouhaitier,Fabrice Uhel,Murielle Grégoire,Arnaud Gacouin,Aurélien Frérou,Baptiste Gaudriot,Claude Bendavid,Sarrah Boukthir,Yves Le Tulzo,Jean‐Philippe Verhoye,Erwan Flécher,Murielle Roussel,Karin Tarte,Jean‐Marc Tadié
出处
期刊:Shock
[Ovid Technologies (Wolters Kluwer)]
日期:2022-10-21
卷期号:58 (6): 476-483
被引量:2
标识
DOI:10.1097/shk.0000000000002007
摘要
ABSTRACT Cardiac surgery with cardiopulmonary bypass (CPB) is associated with an immune paresis that predisposes to the development of postoperative infections and sepsis. Among factors responsible for CPB-induced immunosuppression, circulating myeloid-derived suppressor cells (MDSCs) have been found to induce early lymphocyte apoptosis and lymphocyte proliferation inhibition. However, the mechanisms involved are not fully understood. In this study, we found that the main lymphocyte subsets decreased significantly 24 h after cardiac surgery with CBP. As expected, cardiac surgery with CPB induced a monocytic MDSC expansion associated with an increased T-cell apoptosis and decreased proliferation capacity. Noteworthy, granulocytic MDSCs remain stable. Myeloid-derived suppressor cell depletion restored the ability of T-cell to proliferate ex vivo . After CPB, indoleamine 2,3-dioxygenase activity and IL-10 plasma level were increased such as programmed death-ligand 1 monocytic expression, whereas plasma level of arginine significantly decreased. Neither the inhibition of indoleamine 2,3-dioxygenase activity nor the use of anti–programmed death-ligand 1 or anti–IL-10 blocking antibody restored the ability of T-cell to proliferate ex vivo . Only arginine supplementation restored partially the ability of T-cell to proliferate.
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