CNS tumors are a diverse group of neoplasmsNeoplasm that emerge from a variety of different CNSCentral Nervous System (CNS) cell types. These tumors may be benignBenign, malignantMalignant, or borderline in nature. The majority of high grade glial tumors are fatal, with the exception of pilocytic astrocytomaPilocytic astrocytoma (PCA). Primary malignant CNSCentral Nervous System (CNS) tumors occur at a global annual rate of 2.1 to 5.8 per 100,000 persons. Males are more likely to develop malignant brain tumorsBrain tumor than females, whereas benignBenign meningiomasMeningioma are more common in adult females. Additionally, gender inequalities in non-malignant tumors peak between the ages of 25 and 29 years. Only a small number of genetic variants have been associated with survivalSurvival and prognosisPrognosis. Notably, central nervous systemCentral Nervous System (CNS) (CNS) tumors exhibit significant age, gender, and race variation. Race is another factor that affects the incidenceIncidence of brain and spinal cord tumorsSpinal cord tumors. Different races exhibit variation in terms of the prevalencePrevalence of brain and CNS malignancies. This chapter discusses ongoing research on brainBrain and spinal cord tumor epidemiologyEpidemiology, as well as the associated risks and accompanied disorders.