异恶唑
哌嗪
支原体
化学
碳-13核磁共振
质子核磁共振
最小抑制浓度
体外
组合化学
立体化学
有机化学
生物化学
医学
结核分枝杆菌
病理
肺结核
作者
Yongchang Bi,Xiaodong Chen,Yafei Xue,Kejun Liu,Yiliang Zhang,Qiang Gu
标识
DOI:10.1002/slct.202300551
摘要
A series of piperazine derivatives containing bis-isoxazole were successfully synthesized by the reaction between piperazine and substituted isoxazole derivatives under the optimal reaction condition. The structures of all products were confirmed by IR, HRMS, 1H and 13C NMR. The antibacterial activities of all products against Mycobacteria smegmatis in vitro were tested using rifampin as a positive control. Two compounds presented wonderful anti-mycobacterium activity, and their minimum inhibitory concentrations were respectively 2.60±1.11 μmol/mL and 4.35±0.00 μmol/mL, which indicated that they can be regarded as candidates for development of anti-TB drugs.
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