Associations of Blood Cadmium levels with osteoarthritis among US adults in NHANES 2013–2018

ABSTRACT Background Osteoarthritis is a global public health problem, and limited information is available on the effects of Cd on OA. The purpose of this study is to explore the relationship between Cd and OA. Method Weighted multivariable logistic regression model, trend test, restricted cubic spline (RCS) and stratified analysis were used to study the association between BCd and OA. Results: In the two regression models of weighted multivariable logistic regression analysis, the correlation between BCd and OA was positive. Compared to the lowest quartile of BCd exposure, the highest quartile had a 2.03-fold (95%CI: 1.67,2.47), displaying a dose−response relationship ( P for trend <0.00001). The restrictive cubic spline shows a positive linear relationship between BCd and OA. Conclusion There was a positive linear relationship between BCd and OA, and a dose-response relationship.