Synthesis of Planar Chiral Ferrocenes by Catalytic Desymmetrization Reactions

Abstract Since its discovery in the early 1950s, the sandwich‐type structure of ferrocene has sparked significant research into its applications across various disciplines, including asymmetric synthesis, medicinal chemistry, and materials science. Planar chiral ferrocenes play a crucial role in asymmetric catalysis by serving as essential scaffolds for chiral ligands and catalysts. Classical methods for synthesizing planar chiral ferrocenes often encounter limitations such as low atom economy and lengthy synthesis steps. In contrast, catalytic desymmetrization synthesis strategies offer a promising alternative due to their ability to enhance step and atom efficiency. This review highlights recent advancements in this field, particularly focusing on transition‐metal‐catalyzed C−H functionalization and catalytic enantioselective desymmetrization reactions.