Dorsal pulvinar inactivation leads to spatial selection bias without perceptual deficit

神经科学 感知 扫视 心理学 猕猴 视觉感受 知觉障碍 上丘 认知心理学 眼球运动 生物 解剖
作者
Kristin Kaduk,Melanie Wilke,Igor Kagan
出处
期刊:Scientific Reports [Springer Nature]
卷期号:14 (1) 被引量:1
标识
DOI:10.1038/s41598-024-62056-5
摘要

Abstract The dorsal pulvinar has been implicated in visuospatial attentional and perceptual confidence processing. Pulvinar lesions in humans and monkeys lead to spatial neglect symptoms, including an overt spatial saccade bias during free choices. However, it remains unclear whether disrupting the dorsal pulvinar during target selection that relies on a perceptual decision leads to a perceptual impairment or a more general spatial orienting and choice deficit. To address this question, we reversibly inactivated the unilateral dorsal pulvinar by injecting GABA-A agonist THIP while two macaque monkeys performed a color discrimination saccade task with varying perceptual difficulty. We used Signal Detection Theory and simulations to dissociate perceptual sensitivity (d-prime) and spatial selection bias (response criterion) effects. We expected a decrease in d-prime if dorsal pulvinar affects perceptual discrimination and a shift in response criterion if dorsal pulvinar is mainly involved in spatial orienting. After the inactivation, we observed response criterion shifts away from contralesional stimuli, especially when two competing stimuli in opposite hemifields were present. Notably, the d-prime and overall accuracy remained largely unaffected. Our results underline the critical contribution of the dorsal pulvinar to spatial orienting and action selection while showing it to be less important for visual perceptual discrimination.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
充电宝应助Will3978采纳,获得10
刚刚
Ava应助T拐拐采纳,获得10
1秒前
勤恳化蛹完成签到 ,获得积分10
1秒前
1秒前
宜醉宜游宜睡应助灵长类采纳,获得10
2秒前
2秒前
隐形曼青应助科研通管家采纳,获得10
2秒前
2秒前
Ab-Chen发布了新的文献求助10
2秒前
科研通AI2S应助科研通管家采纳,获得10
2秒前
2秒前
桐桐应助科研通管家采纳,获得10
2秒前
3秒前
毛豆应助科研通管家采纳,获得10
3秒前
3秒前
3秒前
ding应助科研通管家采纳,获得10
3秒前
slow完成签到,获得积分10
3秒前
毛豆应助科研通管家采纳,获得10
3秒前
小蘑菇应助科研通管家采纳,获得10
3秒前
BareBear应助kaola采纳,获得10
3秒前
3秒前
小二郎应助科研通管家采纳,获得10
3秒前
3秒前
CipherSage应助科研通管家采纳,获得10
3秒前
毛豆应助科研通管家采纳,获得10
3秒前
领导范儿应助科研通管家采纳,获得10
3秒前
英俊的铭应助科研通管家采纳,获得10
3秒前
浅尝离白应助科研通管家采纳,获得30
3秒前
华仔应助科研通管家采纳,获得10
4秒前
SciGPT应助科研通管家采纳,获得10
4秒前
4秒前
FashionBoy应助科研通管家采纳,获得10
4秒前
4秒前
SciGPT应助TOTORO采纳,获得10
4秒前
小二郎应助北冰石采纳,获得10
4秒前
Loukas完成签到 ,获得积分10
5秒前
水若冰寒发布了新的文献求助10
5秒前
sbrcpyf发布了新的文献求助10
5秒前
5秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 1800
How Maoism Was Made: Reconstructing China, 1949-1965 800
Barge Mooring (Oilfield Seamanship Series Volume 6) 600
Medical technology industry in China 600
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3312815
求助须知:如何正确求助?哪些是违规求助? 2945259
关于积分的说明 8524020
捐赠科研通 2621043
什么是DOI,文献DOI怎么找? 1433283
科研通“疑难数据库(出版商)”最低求助积分说明 664924
邀请新用户注册赠送积分活动 650271