光热治疗
纳米棒
热电性
材料科学
纳米技术
纳米医学
载流子
光电子学
纳米颗粒
铁电性
电介质
作者
Ying Chen,Yushu Wang,Jingyi Shi,Chunmei Guo,Lina Qi,Jianhang Zhao,Sihan Luo,Hui Zhou,Xiaomei Lü,Quli Fan
标识
DOI:10.1002/adhm.202400781
摘要
Abstract Pyroelectric nanostructures can effectively generate temperature‐mediated reactive oxygen species (ROS) through the pyroelectric effect, providing promise for treating hypoxic tumors; and therefore, the synergistic application of photothermal therapy (PTT) and pyroelectric dynamic therapy (PEDT) presents an intriguing approach for cancer therapy. However, this method still faces challenges in improving pyroelectric catalysis and achieving precise tumor localization. In this study, a nano‐heterojunction based on CeO 2 –BaTiO 3 nanorods (IR1061@PCBNR) is reported, which exhibits highly effective pyroelectric catalysis for simultaneous tumor‐targeted dynamic therapy and gentle photothermal therapy through the utilization of the rich oxygen vacancies. The oxygen vacancies create active sites that facilitate the migration of pyroelectrically‐induced charge carriers, improving charge separation and ROS generation. IR1061@PCBNR also demonstrates high tumor penetration; while, minimizing damage to normal cells. This precise nanomedicine strategy holds great potential for advancing dynamic cancer therapies by overcoming the limitations of conventional approaches.
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