光热治疗
材料科学
炎症
自愈
癌症研究
纳米技术
级联
医学
免疫学
化学
替代医学
病理
色谱法
作者
Yilin Zheng,Fangying Zheng,Ruofei Xu,Xianbin Sun,Jing Yu,Haijun Chen,Yu Gao
标识
DOI:10.1021/acsami.4c09399
摘要
The therapeutic effectiveness of photothermal therapy (PTT) is limited by heat tolerance and PTT-induced inflammation, which increases the risk of tumor metastasis and recurrence. Ferroptosis combined with PTT can achieve significant therapeutic effects. In this work, we designed self-healing photothermal nanotherapeutics to achieve effective PTT with triple-amplified ferroptosis and cascade inflammation inhibition after photothermal treatment. After the ferroptosis-inducing ability of mangiferin (MF) was first elucidated, the nanocomplex PFeM, coordinated by Fe
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