Pre–stereotactic radiosurgery neutrophil-to-lymphocyte ratio predicts post–stereotactic radiosurgery survival of patients with brain metastases concurrently treated with immune checkpoint inhibitors

医学 放射外科 内科学 肿瘤科 接收机工作特性 中性粒细胞与淋巴细胞比率 队列 生存分析 胃肠病学 淋巴细胞 放射治疗
作者
Shoji Yomo,Kyota Oda,Kazuhiro Oguchi
出处
期刊:Journal of Neurosurgery [American Association of Neurological Surgeons]
卷期号:: 1-10
标识
DOI:10.3171/2024.5.jns24259
摘要

OBJECTIVE Treatment with immune checkpoint inhibitors (ICIs) has shown clinical benefit for a wide range of cancer types. The neutrophil-to-lymphocyte ratio (NLR) reportedly correlates with survival time or progression-free survival in patients treated with ICIs. However, NLR has not yet been assessed in patients with brain metastases (BMs) receiving stereotactic radiosurgery (SRS) combined with concurrent ICIs. The authors investigated the predictive impact of NLR on the survival data of patients with BMs who received SRS with concurrent ICIs. METHODS The clinical records of patients who had undergone SRS with concurrent ICIs for BMs between January 2015 and August 2023 were retrospectively analyzed. NLR was calculated using the data obtained from the last examination prior to SRS. The optimal NLR cutoff value was identified by receiver operating characteristic (ROC) curve analysis for time-to-event data (overall survival [OS] ≤ 18 months). OS and intracranial disease progression-free survival (IC-PFS) rates were compared between the two NLR groups. RESULTS Of the 185 eligible patients included, 132 were male. The median (IQR) patient age was 69 (61–75) years. The primary cancers were lung, genitourinary, skin, breast, gastrointestinal, and others in 132, 23, 22, 2, 2, and 4 patients, respectively. The post-SRS median OS and IC-PFS times for the entire cohort were 18.4 (95% CI 14.0–23.1) months and 9.2 (95% CI 6.9–10.8) months, respectively. ROC curve analysis identified the optimal NLR cutoff value for 18-month OS to be 5.0 (area under the curve 0.64, Youden index 0.31). Kaplan-Meier analysis revealed that patients with high NLR (> 5) had a significantly shorter OS (median survival time 10.9 months for 48 patients vs 22.2 months for 137 patients, HR 2.0, 95% CI 1.3–3.0, p < 0.001). Similarly, a significant difference in median IC-PFS was noted: 4.8 months with high NLR versus 10.7 months with low NLR (HR 1.7, 95% CI 1.2–2.5, p = 0.003). CONCLUSIONS The authors found elevated pre-SRS NLR (> 5) to be associated with shorter OS and IC-PFS after SRS with concurrent ICIs for BMs. NLR is a simple, cost-effective, and widely accessible biomarker, which can thus be used for managing patients with BMs receiving SRS concurrently with ICIs. Further investigation in other large datasets is, however, required to validate these findings.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
幼汁汁鬼鬼完成签到,获得积分10
1秒前
1秒前
光亮聪健完成签到,获得积分10
2秒前
乐观发布了新的文献求助10
3秒前
Gu发布了新的文献求助10
3秒前
3秒前
量子星尘发布了新的文献求助10
3秒前
ybheart发布了新的文献求助10
3秒前
任我行完成签到,获得积分10
4秒前
狂野凌珍发布了新的文献求助10
4秒前
4秒前
新明发布了新的文献求助10
4秒前
XuP发布了新的文献求助10
4秒前
4秒前
榴莲小胖完成签到,获得积分10
4秒前
0713完成签到,获得积分10
4秒前
Kristal完成签到,获得积分20
5秒前
CipherSage应助一条小鱼采纳,获得10
5秒前
yar应助自觉的夏蓉采纳,获得10
6秒前
6秒前
imi发布了新的文献求助10
6秒前
zhangsir完成签到,获得积分10
6秒前
7秒前
7秒前
7秒前
张xingxing发布了新的文献求助10
7秒前
小蘑菇应助芒果采纳,获得10
7秒前
隐形曼青应助今今今今朝采纳,获得10
7秒前
慕青应助光亮聪健采纳,获得10
8秒前
日晋斗斤完成签到 ,获得积分10
9秒前
QQLL发布了新的文献求助10
9秒前
9秒前
9秒前
12345发布了新的文献求助20
10秒前
greenspanee完成签到,获得积分10
10秒前
丘比特应助乐观采纳,获得10
10秒前
Lucas应助奥利安费采纳,获得10
10秒前
852应助舒适的小蜜蜂采纳,获得10
11秒前
Gu完成签到,获得积分10
11秒前
11秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974426
求助须知:如何正确求助?哪些是违规求助? 3518788
关于积分的说明 11195842
捐赠科研通 3254946
什么是DOI,文献DOI怎么找? 1797649
邀请新用户注册赠送积分活动 877037
科研通“疑难数据库(出版商)”最低求助积分说明 806130