微生物群
生物
寄主(生物学)
进化生物学
功能(生物学)
疾病
生态学
遗传学
医学
病理
作者
Jacob Wilde,Emma Slack,Kevin R. Foster
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-18
卷期号:385 (6706)
被引量:3
标识
DOI:10.1126/science.adi3338
摘要
Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus on how hosts affect their microbiomes. Hosts exert control over their symbionts through diverse mechanisms, including immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable hosts to shape the ecology and evolution of microbiomes and generate natural selection for microbial traits that benefit the host. Our microbiomes result from a perpetual tension between host control and symbiont evolution, and we can leverage the host’s evolved abilities to regulate the microbiota to prevent and treat disease. The study of host control will be central to our ability to both understand and manipulate microbiotas for better health.
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