CRISPR screens unveil nutrient-dependent lysosomal and mitochondrial nodes impacting intestinal tissue-resident memory CD8+ T cell formation
生物
清脆的
细胞生物学
CD8型
遗传学
基因
免疫系统
作者
Jana Raynor,Nicholas C. Collins,Hao Shi,Cliff Guy,Jordy Saravia,Seon Ah Lim,Nicole M. Chapman,Peipei Zhou,Yan Wang,Yu Sun,Isabel Risch,Haoran Hu,Anil KC,Renqiang Sun,Sharad Shrestha,Hongling Huang,Jon P. Connelly,Shondra M. Pruett‐Miller,Miguel Reina‐Campos,Ananda W. Goldrath,Yasmine Belkaid,Hongbo Chi
Nutrient availability and organelle biology direct tissue homeostasis and cell fate, but how these processes orchestrate tissue immunity remains poorly defined. Here, using in vivo CRISPR-Cas9 screens, we uncovered organelle signaling and metabolic processes shaping CD8
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