Bioactivity-Guided Isolation of Secondary Metabolites from Camellia fascicularis: Antioxidative Antibacterial Activities and Anti-Inflammatory Hypoglycemic Molecular Docking

对接(动物) 传统医学 分离(微生物学) 化学 消炎药 药理学 生物化学 生物 微生物学 医学 护理部
作者
Jiandong Tang,Jingjing Li,Boxiao Wu,Ruonan Li,Junrong Tang,Huan Kan,Ping Zhao,Ying‐Jun Zhang,Weihua Wang,Yun Liu
出处
期刊:Foods [MDPI AG]
卷期号:13 (21): 3435-3435
标识
DOI:10.3390/foods13213435
摘要

Camellia fascicularis is a valuable ornamental, edible, and medicinal plant with promising prospects for bioactivity development. We screened the bioactivity of eight fractions (Fr. A−I) obtained from the ethyl acetate phase of C. fascicularis via silica gel column chromatography. The results indicated that the anti-inflammatory, antioxidative, and antimicrobial active components were mainly found in Fr. B*, E, A, and H; Fr. A–G; and Fr. D–I, respectively. Bioactivity-guided isolation identified 18 secondary metabolites. Compounds 1, 3–5, 7, and 15–18 were isolated from the genus Camellia for the first time in this study, whereas the other compounds were also isolated from this plant for the first time. The structures of these compounds were elucidated through comprehensive spectroscopic techniques. Compounds 1, 9−11, 28, 30, and 31 demonstrated antioxidative activities comparable to those of ascorbic acid, whereas the remaining compounds exhibited diminished antioxidative activity. In terms of antimicrobial activity, compounds 7, 18, 22, and 27 exerted inhibitory potency against Pseudomonas aeruginosa, similar to tetracycline (MIC: 125 µg/mL). Other compounds showed moderate to weak inhibitory effects against Staphylococcus aureus and Escherichia coli (MIC: 250–500 µg/mL). Molecular docking revealed that compounds 2, 36, 41, and 65 showed strong binding affinity for 8ET0, whereas compounds 2, 36, 38, 40, 63, and 65 showed strong binding affinity for 3A4A. This research further increased the diversity of the secondary metabolites of C. fascicularis, laying a foundation for the subsequent development and utilization of this species.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
张坤关注了科研通微信公众号
刚刚
dreamon完成签到,获得积分10
1秒前
寒暄应助jayto采纳,获得10
5秒前
喜羊羊完成签到,获得积分10
6秒前
6秒前
田田发布了新的文献求助10
9秒前
大模型应助香蕉以菱采纳,获得10
11秒前
12秒前
珍惜完成签到,获得积分10
12秒前
ZHOU发布了新的文献求助10
12秒前
14秒前
qiangzhang完成签到 ,获得积分10
14秒前
16秒前
思有完成签到 ,获得积分10
16秒前
17秒前
17秒前
向前发布了新的文献求助30
20秒前
20秒前
20秒前
21秒前
21秒前
21秒前
22秒前
拼搏起眸发布了新的文献求助10
23秒前
完美世界应助干雅柏采纳,获得10
23秒前
谷粱紫槐发布了新的文献求助30
24秒前
ruanyh发布了新的文献求助10
25秒前
25秒前
26秒前
科目三应助Solaris采纳,获得30
26秒前
傲娇幼丝发布了新的文献求助10
26秒前
sophia完成签到 ,获得积分10
28秒前
研友_nxV4m8发布了新的文献求助10
29秒前
Kyros完成签到 ,获得积分10
30秒前
30秒前
30秒前
无心的沉鱼完成签到,获得积分10
31秒前
薰硝壤应助健忘瑾瑜采纳,获得30
31秒前
向前完成签到,获得积分20
31秒前
畅小畅发布了新的文献求助10
31秒前
高分求助中
Sustainability in Tides Chemistry 2000
The ACS Guide to Scholarly Communication 2000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
Pharmacogenomics: Applications to Patient Care, Third Edition 800
Gerard de Lairesse : an artist between stage and studio 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3076162
求助须知:如何正确求助?哪些是违规求助? 2729044
关于积分的说明 7507177
捐赠科研通 2377267
什么是DOI,文献DOI怎么找? 1260526
科研通“疑难数据库(出版商)”最低求助积分说明 611000
版权声明 597164